pancreas_referencesBECKER, T., et al, Use of HTK Solution in Pancreas-Kidney Transplantation, Abstract O1-02, 2001 IPITA, Nov. 2003, p. 2

BECKER, T. et al, Pancreas Transplantation with Histidine-Tryptophan-Ketoglutarate (HTK) Solution and University of Wisconsin (UW) Solution: Is There A Difference?, Journal of the Pancreas, Vol. 8, No. 3, May 2007

This retrospective study, analyzes what impact the preservation solution has in clinical pancreas transplantation.  95 simultaneous kidney-pancreas transplants were reviewed with 48 using HTK, and 47 using UW.  The findings revealed no significant differences in 1, 3, or 12 month patient and graft survival, even in prolonged ischemic times.

BRANDHORST, H. et al, Comparison of Histidine-Tryptophan-Ketoglutarate and University of Wisconsin Solution for Pancreas Perfusion Prior to Islet Isolation, Culture and Transplantation, Transplantation Proceedings, Vol. 27 No. 6, December (1995), 3175-3176

BRENDEL, MD et al, HTK Storage for Human Pancreatic Grafts Prior to Islet Isolation and Transplantation, Transplants 98 Book of Abstracts, XVII World Congress of Transplantation, 1998

ENGLESBE, M. et al, Early Pancreas Transplant Outcomes with Histidine-Tryptophan-Ketoglutarate Preservation: A Multicenter Study, Transplantation 2006; 82: 136-139

ENGLESBE, M. et al, Single Center Comparison of HTK Solution vs. UW Solution in Clinical Pancreas Transplantation, Transplantation Supplement, OP-009

FRIDELL, J. et al, Comparison of Histidine-Tryptophan Ketoglutarate Solution and University of Wisconsin Solution for Organ Preservation in Clinical Pancreas Transplantation, Transplantation, 2004 April 27; 77(8) 1304-1306

FRIDELL, J. et al, Histidine-Tryptophan-Ketoglutarate for Pancreas Allograft Preservation: The Indiana University Experience, American Journal of Transplantation, 2010, 10:1-6

This paper is a retrospective review which looks at the use of Custodiol®  HTK and UW solutions in the 308 pancreas transplants that were performed at the Indiana University Medical Center between 2003 and 2009.  The study evaluates whether 7-day, 9- day, or 1-year graft survival, peak 30 day serum amylase and lipase, HbA1c, or C-peptide level led to an increased risk of allograft pancreatitis or graft loss with either solution.  The authors conclude that there is “no significant difference in 7-day, 90-day or 1-year graft survival” as well as “no clinically significant difference between HTK and UW for pancreas allograft preservation.”

HANSEN, M., et al, Human Islet Isolation of Pancreata Preserved with HTK vs. UW Solution, Abstract #613, American Transplant Congress, May 23, 2005,

HESSE, U.J, et al, Cold Preservation of the Porcine Pancreas with Histidine Tryptophan Ketoglutarate Solution, Transplantation, Vol. 66 No. 9; 1137-1141 Nov. 15, 1993

HESSE, U.J., et al, Pancreas Preservation with HTK in the Pig, Transplantation Proceedings, 29, 3522-3523, 1997

HESSE, U.J., et al, The Use of HTK and UW Solution for 24-hour Cold Storage in Porcine Pancreatic Autotransplantation, XXXII Congress of the European Society for Surgical Research, Abstracts, pg. 102 No. 172

KIN, T., et al, Comparison of HTK Solution vs. UW Solution for Pancreas Preservation Prior to Islet Isolation, Transplantation 83(1); January 2007

LEONHARDT, U., et al, The Effect of Different Solutions for Organ Preservation on Immediate Post-ischemic Pancreatic Function In-vitro, Transplantation Vol. 55; 11-14, January 1993

RIEGE, R., et al, Preservation of the Pancreas for Transplantation, Transplantation Proceedings, 31, 2095-2096, 1999

SALEHI, P., et al, Human Islet Isolations for Pancreata Preserved with Histidine Tryptophan Ketoglutarate vs. University of Wisconsin Solution, Transplantation, 2006; 82: 983-985

SCHNEEBERGER, S. et al, A prospective randomized multicenter trial comparing histidine-tryptophane-ketoglutarate versus University of Wisconsin perfusion solution in clinical pancreas transplantation, Transplant International, 2008, 9:1-8

This randomized study evaluates early pancreas transplant graft function comparing HTK to UW at multiple centers.  Primary endpoint was pancreas graft survival at 6months.  Serum amylase, lipase c-peptide, HbAk and exogenous insulin were also compared.  6 month patient survival rates were comparable amongst both the HTK and UW groups and the authors of the study concluded that both “solutions appear to be equally suitable for perfusion and organ preservation in clinical pancreas transplantation.”

TROISI, R., et al, Structural and Functional Integrity of Porcine Pancreatic Grafts Subjected to a Period of Warm Ischemia and Cold Preservation with Histidine Tryptophan Ketoglutarate or University of Wisconsin Solution, Transplantation, Vol. 75, No. 11, June 2003, 1793-1799

TROISI, R., et al, Suitability of Histidine Tryptophan Ketoglutarate Solution for Pancreas Preservation and Transplantation from Non-Heart Beating Donors, Eur Surg Res;2002; Supp. 1: No. 53

TROISI, R., et al, Physiologic and Metabolic Results of Pancreatic Cold Storage with Histidine Tryptophan Ketoglutarate Solution in the Porcine Autotransplantation Model, Transplant International (2000), 13;98-105

TROISI, R. et al, Segmental Porcine Pancreatic Autotransplantion as Model for Pancreas Autotransplantation Studies Using Two Different Techniques for Vascular Reconstruction, Journal of Investigative Surgery, 13;203-211, 2000