HTK SolutionPancreas Transplantation
Pancreas Transplantation with Custodiol® HTK
• HTK is comparable to UW. Both solutions have been shown to be safe for Pancreas Transplantation.11
• The key to successful pancreas transplantation is a safe organ procurement and preservation technique.11
• In the postoperative course, both serum pancreatic enzymes
decrease rapidly from day 2
with no further significant
differences between the two groups of patients.11
• …especially in cases of prolonged donor operations,
the flush volume should be reduced after the initial
rapid flush in order to cool down the organs.11
• A lack of technical procurement skills might raise the
risk of graft pancreatitis.11
HTK preservation showed equal patient and graft survival rates compared to UW preservation in clinical pancreas transplantation.
Organ Preservation with Histidine-Tryptophane Ketoglutarate Solution in Clinical Pancreas Transplantation7
• There were no episodes of primary graft function
HTK is safe for pancreas preservation with results comparable to UW. In this study, Custodiol® HTK was found:
• ...reliable preservation of pancreas allografts in terms of patient and graft survival and early graft function.
• All patients are off insulin with excellent glucose control by discharge.
• Results consistent with University of Pittsburgh12 and Michigan13 groups in showing no significant difference in early clinical outcomes between UW and HTK cold preservation.
• Serum fasting blood glucose and serial amylase remained comparable at all intervals post-transplantation to those of a historical UW cohort.
References
1. Data on file. Essential Pharmaceuticals, LLC.
2. Erhard J, Lange R, Scherer R, et al. Comparison of histidine-tryptophan- ketoglutarate (HTK) solution versus University of Wisconsin (UW) solution for organ preservation in human liver transplantation. A prospective, randomized study. Transplant Int. 1994;7:177-181
3. Gebhard MM,, Kirlum HJ, Schlegel C. Organ preservation with the solution HTK. In: Hesse UJ, de Hemptinne B, eds. Organ Preservation with HTK and UW Solution: Update on Clinical Use and Experimental Studies. Lengerich, Germany: Pabst Science Publishers; 1999:75-87.
4. Ringe B, Braun F, Moritz M, Zeldin G, Soriano H, Meyers W. Safety and efficacy of living donor liver preservation with HTK solution. Transplant Proc. 2005;37:316-319.
5. Lynch RJ, Kubus J, Chenault RH, Pelletier SJ, Campbell DA, and Englesbe MJ. Comparison of Histidine-Trytophan-ketogluterate and University of Wisconsin Preservation in renal Transplantation. American Journal of Transplantation. 2008;8:567-573.
6. Agarwal A, Murdock P, Fridell JA. Comparison of histidine-tryptophan- ketoglutarate (HTK) solution and University of Wisconsin solution in prolonged cold preservation of kidney allografts. Transplantation. 2006;81:480-482.
7. Agarwal A, Powelson JA, Goggins WC, Milgrom ML, and Fridell JA. Organ preservation with histidine-tryptophan-ketoglutarate solution in clinical pancreas transplantation: an update of the Indiana University Experience. Transplant Proceedings. 2008;40:498-501
8. Pokorny H, Grünberger T, Rockenschaub S, et al. Liver transplantation with HTK perfused organs—a multicenter study. Transplantation. 2002;74:36-37. Abstract
9. Welling TH, Heidt DG, Englesbe MJ, Magee JC, et al. Biliary complications following liver transplantation in the model for end-stage liver disease era: effect of donor, recipient, and technical factors. Liver Transpl. 2008;14:73-80
10. Mangus RS, Fridell JA, Vianna RM, Milgrom MA, et al. Comparison of histidine-tryptophan-ketoglutarate solution (HTK) and University of Wisconsin solution (UW) in extended criteria liver donors. Liver Transpl. 2008;14:365-373.5. (Brown)
11. Becker T, Ringe B, Nyibata M, Meyer zu Vilsendorf A, Schrem H, Lück R, et al. Pancreas transplantation with histidine-tryptophanketoglutarate (HTK) solution and University of Wisconsin (UW) solution: is there a difference? Journal of the Pancreas (Online) 2007;8(3):304-311.
12. Potdar S, Malck S, Eghtesad B, et al: Initial experience using histidine- tryptophan-ketogluterate solution in clinical pancreas transplantation. Clin Transplant 18:661, 2004
13. Englesbe MJ, Moyer A, Kim DY et al: Early Pancreas transplant outcomes with histidine-tryptophan-ketogluterate preservation: a multicenter study. Transplantation 82:136, 2006
14. Weiselthaler GM, Chevtchik O, Konestschny R, et al. Improved graft function using a new myocardial preservation solution: Celsior. Preliminary data from a randomized prospective study. Transplant Proc. 1999;31:2067-2068.
15. CUSTODIOL® [package insert]. Newtown, PA: Essential Pharmaceuticals, LLC;2006.
16. Ackerman J, Gross W, Mory M, Schaefer M, Gebhard, MM. Celsior versus Custodiol® : Early postichemic recovery after cardioplegia and ischemia at 5°C. Ann Thorac Surg. 2002;74:522-529.